Use of baxdrostat was associated with a reduction in office-measured systolic blood pressure of around 9 mm Hg at 12 weeks and reductions in 24-hour ambulatory systolic blood pressure of around 15 mm Hg in the BaxHTN trial.
Can Antibiotics Wait for Blood Cultures in Endocarditis?In clinically stable patients with suspected or confirmed infective endocarditis (IE), deferring antimicrobial treatment until blood culture results were available was not associated with 30-day mortality or worse clinical outcomes compared with immediate antimicrobial treatment.
Statin Use May Mitigate Major Cardiovascular Event Risk With Tofacitinib in Rheumatoid ArthritisMost patients with rheumatoid arthritis (RA) and cardiovascular risk factors did not receive statins at baseline, and few initiated them later. Statin use in tofacitinib-treated patients with a history of atherosclerotic cardiovascular disease (ASCVD) was linked to fewer major adverse cardiovascular events (MACE). No difference in incident MACE was seen between tofacitinib users and TNF-inhibitor users when statins were used.
Gene Variants Drive Heart Risks in Polycystic Kidney DiseaseIn patients with autosomal dominant polycystic kidney disease (ADPKD), left ventricular hypertrophy was independently associated with PKD1 gene mutations, and mitral valve prolapse was associated with truncating PKD1 mutations.
Pregabalin Tied to Elevated Heart Failure RiskThe results of a recent study published in JAMA Network Open show a substantially higher risk for heart failure (HF) in people taking the antiseizure medication pregabalin for chronic noncancer pain. The risk is particularly high for people with preexisting cardiovascular disease.
Azoospermia May Signal Hidden Health RisksAzoospermia, the complete absence of sperm in the ejaculate, affects approximately 1 in 100 men and accounts for up to 20% of male infertility cases. Once considered only a fertility problem, azoospermia is now linked to broader health risks.
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