
For patients with clinically significant atherosclerotic cardiovascular disease and a very high risk of recurrence, a threshold of less than 55 mg/dL has been defined.
This change fundamentally alters the approach to conducting any discussions about statins as part of secondary prevention.
A 2026 meta‑analysis found no evidence that statin therapy causes most of the side effects listed in statin prescribing information, including memory loss, depression, sleep disorders, erectile dysfunction, fatigue, and headache.