Cardiovascular disease in Sickle cell: mechanisms, diagnostics and therapeutic advances

The researchers focused on new diagnostic tools, such as cardiac magnetic resonance imaging with T2* mapping and extracellular volume determination, speckle-tracking echocardiography, and invasive stress testing, which enable the identification of a distinct phenotype combining restrictive cardiomyopathy and high-output heart failure. In addition, practical algorithms for risk stratification and disease monitoring were presented, as well as evidence-based approaches to the treatment of sickle cell disease, including the use of hydroxyurea, blood transfusions, anticoagulants, and gene therapy.

https://doi.org/10.1136/heartjnl-2025-325837

 

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