The results are from a subanalysis of the Swiss-Apero trial, a randomized comparative trial of the Watchman and Amulet devices for LAAC.
"Our observational data support to use of CT for LAAC procedure planning," senior investigator Lorenz Räber, MD, PhD, said in an interview. "This is not very surprising given the high variability of the LAA anatomy and the associated complexity of the procedure." Dr. Räber is director of the catheterization laboratory at Inselspital, Bern (Switzerland) University Hospital.
The study, published online: Cardiovascular Interventions, included 219 LAAC procedures in which the operators performed coronary CT angiography (CTTA) beforehand. When the investigators designed the study, LAAC procedures were typically planned using TEE alone, and so participating operators were blinded to preprocedural CCTA imaging. Soon after the study launch, European cardiology societies issued a consensus statement that included CCTA as an option for procedure planning. So the Swiss-Apero investigators changed the subanalysis protocol to unblind the operators – that is, they were permitted to plan LAAC procedures with CCTA imaging in addition to TEE. In this subanalysis, most patients had implantation with blinding to CCTA (57.9% vs. 41.2%).