Ovarian Reserve Decline Patterns Linked to Cardiovascular Risk After Menopause

The researchers analyzed data from 1,131 women aged 42-52 years who participated in the longitudinal cohort study "Women's Health across the Country" between 1996 and 1997. They identified two different patterns of decreasing levels of anti-Muller hormone (AMH) during menopause. AMH is an indicator of ovarian reserve.

Women with lower baseline AMH levels and slower decline had higher rates of cardiovascular risk after menopause than women with higher baseline levels and faster decline. They were also less likely to complain of frequent hot flashes and night sweats. Both groups reached menopause at about the same age.

 

Article Key Points
  • Low/slow AMH decline pattern linked to ↑ postmenopausal CVD risk score.
  • High/fast AMH decline pattern had lower postmenopausal CVD risk.
  • Both AMH trajectories reached menopause at similar ages.
  • Low/slow group had fewer frequent vasomotor symptoms despite worse cardiometabolic profile.
  • Routine serial AMH testing for CVD risk stratification remains premature.

 

https://www.medscape.com/viewarticle/ovarian-reserve-decline-patterns-linked-cardiovascular-risk-2026a100161l